Anti-Progesterone in Environmental Water
Past research has shown that endocrine-disrupting compounds (EDCs), including steroid hormones, synthetic estrogens and progestins found in oral contraceptives, are present in water supplies. This problem remains an environmental and health concern, especially given the widespread use of contraceptives and the increased prevalence of medication abortion in recent years. These compounds have a number of deleterious effects on human and animal biology, particularly aquatic animals. Small amounts of these chemicals (parts per trillion) can affect the endocrine system of animals and humans. Progestins, including specifically the anti-progesterone synthetic steroid hormone mifepristone, have been found to have disruptive effects on the fertility and reproduction of fish. Moreover, further highlighting the potential for environmental toxicity and contamination, the FDA recommends treating any unused mifepristone pills as hazardous waste.